{"id":1565,"date":"2022-12-24T19:35:58","date_gmt":"2022-12-24T19:35:58","guid":{"rendered":"https:\/\/patologika.com\/novosite\/?page_id=1565"},"modified":"2023-01-11T17:19:36","modified_gmt":"2023-01-11T17:19:36","slug":"lipossarcoma-desdiferenciado","status":"publish","type":"page","link":"https:\/\/patologika.com\/novosite\/lipossarcoma-desdiferenciado\/","title":{"rendered":"Lipossarcoma Desdiferenciado"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"1565\" class=\"elementor elementor-1565\">\n\t\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-cc6e661 elementor-section-full_width elementor-section-height-default elementor-section-height-default exad-glass-effect-no exad-sticky-section-no\" data-id=\"cc6e661\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-91c97d3 exad-glass-effect-no exad-sticky-section-no\" data-id=\"91c97d3\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f35eaf5 elementor--h-position-left animated-slow elementor--v-position-middle elementor-arrows-position-inside exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-slides\" data-id=\"f35eaf5\" data-element_type=\"widget\" data-settings=\"{&quot;navigation&quot;:&quot;arrows&quot;,&quot;transition&quot;:&quot;fade&quot;,&quot;_animation&quot;:&quot;none&quot;,&quot;autoplay&quot;:&quot;yes&quot;,&quot;pause_on_hover&quot;:&quot;yes&quot;,&quot;pause_on_interaction&quot;:&quot;yes&quot;,&quot;autoplay_speed&quot;:5000,&quot;infinite&quot;:&quot;yes&quot;,&quot;transition_speed&quot;:500}\" data-widget_type=\"slides.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! 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elementor - v3.6.7 - 03-07-2022 *\/\n.elementor-heading-title{padding:0;margin:0;line-height:1}.elementor-widget-heading .elementor-heading-title[class*=elementor-size-]>a{color:inherit;font-size:inherit;line-height:inherit}.elementor-widget-heading .elementor-heading-title.elementor-size-small{font-size:15px}.elementor-widget-heading .elementor-heading-title.elementor-size-medium{font-size:19px}.elementor-widget-heading .elementor-heading-title.elementor-size-large{font-size:29px}.elementor-widget-heading .elementor-heading-title.elementor-size-xl{font-size:39px}.elementor-widget-heading .elementor-heading-title.elementor-size-xxl{font-size:59px}<\/style><h2 class=\"elementor-heading-title elementor-size-default\">LIPOSSARCOMA DESDIFERENCIADO<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-54f69a8 exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-heading\" data-id=\"54f69a8\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Apresenta\u00e7\u00e3o cl\u00ednica<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-871c8d0 exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-text-editor\" data-id=\"871c8d0\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.6.7 - 03-07-2022 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#818a91;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#818a91;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t<p>Paciente do sexo masculino, 58 anos. Dados cl\u00ednicos: Paciente com hist\u00f3rico de distens\u00e3o abdominal h\u00e1 08 meses. Em investiga\u00e7\u00e3o, diagn\u00f3stica evidenciou tumor em regi\u00e3o retroperitoneal<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d7f3cb0 exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-heading\" data-id=\"d7f3cb0\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">An\u00e1lise do caso<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b4b7b51 exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-text-editor\" data-id=\"b4b7b51\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Os cortes histol\u00f3gicos revelam sarcoma representado por componente fusocelular mitoticamente ativo e componente lipog\u00eanico bem diferenciado (imagem 01), incluindo LIPOBLASTOS com caracter\u00edstico citoplasma vacuolado e n\u00facleos hipercrom\u00e1ticos. H\u00e1 transi\u00e7\u00e3o abrupta entre esses dois componentes (imagem 02). Os achados s\u00e3o indicativos de\u00a0 LIPOSSARCOMA DESDIFERENCIADO. Trata-se de neoplasia mesenquimal com elevada taxa de recorr\u00eancia (&gt;40%) e potencial de dissemina\u00e7\u00e3o metast\u00e1tica (15-20%).<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d442a5f exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-image\" data-id=\"d442a5f\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.6.7 - 03-07-2022 *\/\n.elementor-widget-image{text-align:center}.elementor-widget-image a{display:inline-block}.elementor-widget-image a img[src$=\".svg\"]{width:48px}.elementor-widget-image img{vertical-align:middle;display:inline-block}<\/style>\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"800\" height=\"600\" src=\"https:\/\/patologika.com\/novosite\/wp-content\/uploads\/2022\/12\/imagem01_2.jpg\" class=\"attachment-large size-large\" alt=\"\" loading=\"lazy\" srcset=\"https:\/\/patologika.com\/novosite\/wp-content\/uploads\/2022\/12\/imagem01_2.jpg 800w, https:\/\/patologika.com\/novosite\/wp-content\/uploads\/2022\/12\/imagem01_2-300x225.jpg 300w, https:\/\/patologika.com\/novosite\/wp-content\/uploads\/2022\/12\/imagem01_2-768x576.jpg 768w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-61ce106 exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-text-editor\" data-id=\"61ce106\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h2 style=\"font-family: Roboto, sans-serif; font-size: 14px;\" data-elementor-setting-key=\"title\" data-pen-placeholder=\"Digite aqui...\"><span style=\"font-family: Inter, sans-serif; font-size: 1rem;\">Imagem 01<\/span><span style=\"font-family: Inter, sans-serif; font-weight: 400; font-size: 1rem;\"> &#8211; \u00c1rea lipog\u00eanicas bem diferenciadas<\/span><\/h2>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e8afb21 exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-image\" data-id=\"e8afb21\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"800\" height=\"600\" src=\"https:\/\/patologika.com\/novosite\/wp-content\/uploads\/2022\/12\/imagem02_2.jpg\" class=\"attachment-large size-large\" alt=\"\" loading=\"lazy\" srcset=\"https:\/\/patologika.com\/novosite\/wp-content\/uploads\/2022\/12\/imagem02_2.jpg 800w, https:\/\/patologika.com\/novosite\/wp-content\/uploads\/2022\/12\/imagem02_2-300x225.jpg 300w, https:\/\/patologika.com\/novosite\/wp-content\/uploads\/2022\/12\/imagem02_2-768x576.jpg 768w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d50bc6f exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-text-editor\" data-id=\"d50bc6f\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h2 data-elementor-setting-key=\"title\" data-pen-placeholder=\"Digite aqui...\"><span style=\"font-family: Inter, sans-serif; font-size: 1rem;\">Imagem 02<\/span><span style=\"font-family: Inter, sans-serif; font-size: 1rem; font-weight: 400;\">\u00a0&#8211;\u00a0<\/span><span style=\"font-size: 16px; font-weight: 400;\">\u00c1rea de transi\u00e7\u00e3o abrupta<\/span><\/h2>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3df6221 exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-heading\" data-id=\"3df6221\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Conclus\u00e3o<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b8c56bb exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-text-editor\" data-id=\"b8c56bb\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Lipossarcoma desdiferenciado<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6ec4fa2 exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-heading\" data-id=\"6ec4fa2\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Discuss\u00e3o<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9c288b6 exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-text-editor\" data-id=\"9c288b6\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>O lipossarcoma bem diferenciado (WDL) e o lipossarcoma desdiferenciado (DDL) formam o maior subgrupo de lipossarcomas e representam um espectro morfol\u00f3gico e comportamental de 1 entidade patol\u00f3gica, que surge tipicamente no meio ao final da vida adulta, mais frequentemente no retroperit\u00f4nio ou extremidades. DDL \u00e9 definido como sarcoma n\u00e3o lipog\u00eanico justaposto ao WDL, ocorre como uma recorr\u00eancia de WDL ou que pode surgir de novo e, tipicamente, tem a apar\u00eancia de sarcoma pleom\u00f3rfico indiferenciado ou de c\u00e9lulas fusiformes. DDL tem tend\u00eancia para recorr\u00eancia local, enquanto met\u00e1stases \u00e0 dist\u00e2ncia s\u00e3o mais raras e o comportamento est\u00e1 relacionado ao s\u00edtio anat\u00f4mico, com neoplasias retroperitoneais apresentando progn\u00f3stico significativamente pior. A ressec\u00e7\u00e3o cir\u00fargica continua sendo a base do tratamento, e as op\u00e7\u00f5es m\u00e9dicas para pacientes com doen\u00e7a recorrente ou metast\u00e1tica agressiva s\u00e3o limitadas. DDL compartilham anormalidades gen\u00e9ticas semelhantes ao WDL, com amplifica\u00e7\u00f5es de alto n\u00edvel do cromossomo 12q14-15, incluindo oOncogenes do ciclo celular MDM2 e CDK4 e DDL abrigam altera\u00e7\u00f5es gen\u00e9ticas adicionais, particularmente coamplifica\u00e7\u00f5es de 6q23 e 1p32. Novas terapias direcionadas aos produtos g\u00eanicos do cromossomo 12 est\u00e3o sendo testadas em ensaios cl\u00ednicos.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-80057d3 exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-heading\" data-id=\"80057d3\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Refer\u00eancias<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7d03400 exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-text-editor\" data-id=\"7d03400\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Refer\u00eancias: 1.McCormick D, Mentzel T, Beham\u00a0 a, Fletcher CD. Dedifferentiated liposarcoma. Clinicopathologic analysis of 32 cases suggesting a better prognostic subgroup among pleomorphic sarcomas. Am J Surg Pathol [Internet]. 1994;18(12):1213\u201323. 2.Thway K, Jones RL, Noujaim J, Zaidi S, Miah AB, Fisher C. Dedifferentiated Liposarcoma: Updates on Morphology, Genetics, and Therapeutic Strategies. Adv Anat Pathol [Internet]. 2016;23(1):30\u201340.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>LIPOSSARCOMA DESDIFERENCIADO Apresenta\u00e7\u00e3o cl\u00ednica Paciente do sexo masculino, 58 anos. Dados cl\u00ednicos: Paciente com hist\u00f3rico de distens\u00e3o abdominal h\u00e1 08 meses. Em investiga\u00e7\u00e3o, diagn\u00f3stica evidenciou tumor em regi\u00e3o retroperitoneal An\u00e1lise do caso Os cortes histol\u00f3gicos revelam sarcoma representado por componente fusocelular mitoticamente ativo e componente lipog\u00eanico bem diferenciado (imagem 01), incluindo LIPOBLASTOS com caracter\u00edstico citoplasma [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":[],"_links":{"self":[{"href":"https:\/\/patologika.com\/novosite\/wp-json\/wp\/v2\/pages\/1565"}],"collection":[{"href":"https:\/\/patologika.com\/novosite\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/patologika.com\/novosite\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/patologika.com\/novosite\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/patologika.com\/novosite\/wp-json\/wp\/v2\/comments?post=1565"}],"version-history":[{"count":34,"href":"https:\/\/patologika.com\/novosite\/wp-json\/wp\/v2\/pages\/1565\/revisions"}],"predecessor-version":[{"id":3143,"href":"https:\/\/patologika.com\/novosite\/wp-json\/wp\/v2\/pages\/1565\/revisions\/3143"}],"wp:attachment":[{"href":"https:\/\/patologika.com\/novosite\/wp-json\/wp\/v2\/media?parent=1565"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}